Automorphisms of smooth canonically polarized surfaces in positive characteristic

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Vector fields on canonically polarized surfaces

This paper investigates the geometry of canonically polarized surfaces defined over a field of positive characteristic which have a nontrivial global vector field, and the implications that the existence of such surfaces has in the moduli problem of canonically polarized surfaces. In particular, an explicit integer valued function f(x) is obtained with the following properties. If X is a canonically polarized surface defined over an algebraically closed field of characteristic p>0 such that p>f(K2X) and X has a nontrivial global vector field, then X is unirational and the algebraic fundamental group is trivial. As a consequence of this result, large classes of canonically polarized surfaces are identified whose moduli stack is Deligne-Mumford, a property that does not hold in general in positive characteristic

Actions of μp\mu_p on canonically polarized surfaces in characteristic p>0

This paper studies the existence of non trivial $\mu_p$ actions on a canonically polarized surface X defined over an algebraically closed field of characteristic p>0. In particular, an explicit function $f(K_X^2)$ is obtained such that if $p>f(K_X^2)$, then there does not exist a non trivial $\mu_p$-action on X. This implies that the connected component of the automorphism scheme of X containing the identity is either smooth or is obtained by successive extensions by $\alpha_p$

Changes in kidney function in a population with essential hypertension in real life settings

Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a large number of randomized controlled trials. Observational studies, although scarcely been used, outpatient can reflect everyday practice, where drug exposures vary over time, and may provide an alternative for detecting longitudinal changes in kidney function. Materials and Methods. We applied mixed model repeated measures analysis to investigate the effect of antihypertensive drug categories and their combinations on kidney function change over time in a cohort of 779 patients with essential hypertension, using the data from a Greek hypertension outpatient clinic. Antihypertensive drugs were grouped in 5 categories. Their effect was evaluated and their combinations with and without renin-angiotensin-system inhibitors (RASI) to each other. In addition, the combination of RASI with calcium channel blockers (CCBs) was studied. Results. Diuretics, RASI, CCBs, and beta-blockers had a significant renoprotective and blood pressure lowering effect. Combinations with RASI had a smaller beneficial effect on kidney function compared to CCBs (0.75 mL/min/1.73 m2 per year of drug use versus 0.97 mL/min/1.73 m2). There was no additional effect when combining RASI with CCBs. However, the lowering effect on systolic blood pressure was greater (-0.83 mm Hg per year of drug use, P < .001). Conclusions. RASI were found to have a smaller, although significant, renoprotective effect. There was no additional effect on kidney function when combining RASI with CCBs

Wafer Map Defect Pattern Recognition using Imbalanced Datasets

The accurate and automatic inspection of wafer maps is vital for semiconductor engineers to identify defect causes and to optimize the wafer fabrication process. This research work seeks to address the pattern recognition task for the identification of defects in wafer maps, by developing a deep Convolutional Neural Network (CNN) classifier. The proposed CNN-based model utilizes various pre- and post-processing tools and is applied on the public but highly imbalanced industrial dataset WM-811K. To handle imbalance, a methodology of treating each class individually is proposed by applying different processing techniques for down-sampling, splitting and data augmentation based on the number of samples. The proposed model achieves 95.3% accuracy and 93.78% macro F1-score and outperformes other models in the related literature concerning the identification of the majority of classes. © 2022 IEEE

Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium-hydrogen exchange in hypertensive patients with Type 2 diabetes

To investigate the effect of oral calcium (Ca2+) supplementation on insulin sensitivity measured by the euglycaemic hyperinsulinaemic clamp, intraplatelet cationic concentration of Ca2+ ([Ca2+](i)) and the transmembrane sodium-hydrogen exchanger (NHE) activity in erythrocytes in subjects with Type 2 diabetes and hypertension. In this parallel randomized controlled single-blinded trial, 31 patients were allocated to receive either 1500 mg of Ca2+ orally, daily (n = 15) or no treatment (n = 16) for 8 weeks. At baseline and at the end of the 8-week period insulin sensitivity, [Ca2+](i) and the first isoform of NHE (NHE-1) activity were measured. At the end of the study, subjects who received Ca2+ supplementation showed higher insulin sensitivity (Delta M-value 0.32 +/- 0.5 mmol/min P < 0.05) and lower [Ca2+](i) (125.0 +/- 24.7 to 80.4 +/- 10.6 nmol/l, P < 0.05, mean +/- sem) and NHE-1 activity (79.5 +/- 10.0 to 52.1 +/- 6.4 mmol Na/l red cell/h, P < 0.05). None of the above parameters were changed in the control group. Simple regression analysis demonstrated the change in [Ca2+](i) significantly determined insulin sensitivity change (beta = -0.36, P < 0.05). Oral Ca2+ supplementation improves insulin sensitivity in patients with Type 2 diabetes and hypertension. These changes are likely to be mediated by changes in intracellular ionic Ca2+. NHE-1 activity was also reduced after Ca2+ supplementation but its role in insulin sensitivity requires further investigation